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Among 17 members in humans and 16 members in mice, PARP1 alone is responsible for about 90% of all NAD + used by the PARP protein family [49]

It can be seen that the inhibition of GPX4, the depletion of glutathione and the increase of lipoxygenase activity promote the accumulation of polyunsaturated fatty acids and the production of fatty acid-free radicals, thereby inducing the occurrence of cell ferroptosis, cause tissue damage, and further aggravate pathological processes including diabetes, periventricular leukomalacia, acute kidney disease, cancer, and other diseases (Otasevic et al., 2021)

Polydorou, C., Mpekris, F., Papageorgis, P., Voutouri, C., & Stylianopoulos, T

Molecules 24:2030 Koudelka S, Turanek Knotigova P, Masek J, Prochazka L, Lukac R, Miller AD, Turanek J (2015) Liposomal delivery systems for anti-cancer analogues of vitamin E

Toso, J

In addition, hepatic factors and the signaling proteins secreted by the liver can reach the eye and cause oxidative stress and inflammation