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Inflammatory cytokines, such as TNF, IFN-, and IL-6, impair HSC self-renewal and differentiation, leading to accelerated aging and depletion of the HSC pool

Teijeira, A

At an advanced stage, recovery may take several months and may be incomplete (5)

Does the gut microbiota modulate host physiology through polymicrobial biofilms

When a compound is ingested orally, it goes through the digestive system and is processed by the liver before it ever reaches the rest of the body

This may directly inhibit GPX4 activity, thereby impairing cellular capacity to eliminate lipid peroxides and ultimately inducing ferroptosis ( Figure 2 )