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The mechanisms are fundamentally different, and that difference has significant clinical implications

Diabetes constituted the majority of indications (n = 16,863, 58.2%), followed by weight control (n = 1,352, 4.7%) and non-diabetic blood glucose abnormalities (n = 556, 1.9%)

And once again, they tried to make fetch happen without titration, but then backtracked to show that, well, actually, titration reduces nausea, vomiting and diarrhea

Grover S, Srivastava A, Lee R, Tewari AK, Te AE

The possible role of MTX in psoriasis is related to its role in inhibiting dihydrofolate reductase (DHFR) and, therefore, in the activation of folic acid

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