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For example, exposing endothelial cells to MOTS-c in vitro attenuated dysfunction caused by oxidative stress, in part by activating AMPK and suppressing inflammatory pathways (such as the MAPK/NF-B pathway) in those cells

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These medications had powerful anti-inflammatory effects that extended well beyond metabolic improvement

(1) M G Murphy, L M Plunkett, B J Gertz, et al (1998) MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism Journal of Clinical Endocrinology & Metabolism, 1998 Feb, Volume 83 (Issue 2), Pages 320-5

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