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has received advisory board/consulting honoraria from Amgen, Bristol Myers Squibb/Celgene, Janssen, Novartis, PharmaMar, Sanofi, and Takeda

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Ethics statement The animal study was reviewed and approved by The calf and mouse study were reviewed and approved by the Veterinary Science Animal Care Committee of the University of Calgary, protocols AC18-0059 and AC17-0220, respectively

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