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Nat Rev Endocrinol (2014) 10:13642

Theoretically, if homocysteine concentrations become extremely low, substrate availability for glutathione synthesis could also be reduced

Sh-Polypeptide-59 is a peptide

The majority of SAHHs/SIHHs analysed in this work containing a shortened C-terminus are (hyper-)thermophilic, confirming the assumption 36 that the length of the C-terminus correlates with the thermophilicity of the enzymes 46