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After equilibrated with molecular dynamics (MD) simulation, the final structure of GSDME was employed for molecular docking, where the docking center was set to each predictive Cys site (a total of 13 Cys sites) of the protein

Recent research has shown that oxidative stress and photoreceptor impairment may occur before the initial vascular pathology in diabetes (257)

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They further demonstrated that EGLN1 and c-Myc directly activated the expression of LSH by inhibiting HIF-1 (Jiang et al., 2017b)

Rather than targeting a single function, it influences several processes involved in aging and tissue repair

Deficiencies in ATP binding cassette subfamily D member 3 (ABCD3), an ABC transporter found in the peroxisomal membrane, result in bile acid synthesis abnormalities