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Microbe-derived neuroactive compounds extend the repertoire beyond SCFAs

In the preclinical literature it is described across six complementary axes: angiogenesis via VEGFR2/eNOS/NO, regulation of FAK-paxillin signalling, protection of the endothelium and the gastric-intestinal mucosa, modulation of the brain-gut axis with the NO pathway, tendon maturation with fibroblast proliferation, and cytoprotection as a common denominator

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Bone changes, including easy fractures, may occur, especially in older people

Several reports document platelet normalization after starting a gluten-free diet

Taking this feature into account, GST can be useful for monitoring the protein production and purification via its catalytic activity, and the purification of GST fusion proteins can be easily performed by affinity chromatography using glutathione derivates immobilized into a solid support (Viljanen et al., 2008)