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Because IGF-1 is involved in the hearts response to injury, improves contractility, and reduces cardiac fibrosis, it could be used to improve heart function after myocardial infarction

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Analogously GH deficiency in rodents is associated with delayed sexual maturation [7, 18], and GnRH immunoneutralization delays sexual maturation in rats and reduces testicular mass, spermatogenesis, and follicle-stimulating hormone responsiveness [19]