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Lysates were passed through 0.22-m-sized filters to remove any bacterial cells or debris

10.1016/j.mad.2016.04.005 Mech

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Although OA pathogenesis is exceedingly complex, recent studies underscore the multifactorial nature of the disease, involving mechanical overload, inflammatory responses, metabolic abnormalities, and cell death ( Cartilage deterioration and subchondral bone remodeling are hallmarks of OA

Conclusions and future directions In this review we have emphasized the role of synaptic activity in the remodeling of GABAergic synapse structure and discussed the possible roles of structural plasticity in sensory processing and memory formation

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