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Hum Reprod Update (2014) 20(6):86983

La B12 peut apparatre comme normale, mais si le mcanisme de transport nest pas satur, alors en cas de dficit alimentaire, la transcobalamine pourrait ne pas dlivrer la vitamine aux tissus (carence tissulaire), tandis que les valeurs sanguines continueraient dapparatre normales

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STEP THREE: SAMPLE INSPECTION

Vitamin B12 Medicine Interactions Chloramphenicol: bacteriostatic antibiotic can interfere with red blood cell response to supplemental Vit B12 Proton pump inhibitors: omeprazole and lansoprazole, etc., slow gastric acid release and may interfere with VIt B12 absorption from food H2-receptor antagonists: cimetidine, famotidine and ranitidine slow the release of hydrochloric acid into the stomach and interfere with Vitamin B12 absorption from food Metformin: might reduce absorption of Vitamin B12 due to altered intestinal motility, increased bacterial overgrowth, etc

When extracellular thiamine concentrations are below 2 mmol/L, active transport via THTR2 is possible