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PMID: 8298609)

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Elevated activating transcription factor 4 and glucose-regulated 78 Kda protein levels correlate with inflammatory cytokines in the aqueous humor and vitreous of proliferative diabetic retinopathy

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Direct impacts of E

In turn, these compromised mitochondria produce excess ROS, which further stimulates pro-inflammatory gene expression through MAPK and NF-B signaling, creating a self-reinforcing feedback loop that amplifies the inflammatory cytokines response