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109,170 However, the side effects associated with targeting - and -secretases arise because these enzymes have a wide range of substrates that are vital in other physiological processes

Natural ingredients regulate lipid peroxidation through various targets and pathways, mainly including the System X c , Nrf2/GPX4, and Nrf2/HO-1

For example, one of the main characteristics of Parkinsons disease is defective PINK/PARKIN-mediated mitophagy

It is potentially possible that inhaled nanoparticles reach the olfactory nerve and travel to the brain through axons (Oberdrster et al., 2004)

Microglial ferroptosis has been shown to amplify neurotoxicity by releasing pro-inflammatory mediators (such as TNF- and IL-1), and ferroptosis-related genes including ACSL4 and ALOX15 are highly enriched in microglia within PVL lesions

Glutathione synthesis starts with the reaction between cysteine and glutamate to form -glutamyl-cysteine