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"We recognize these make up a significant part of the available products and many have played a disproportionate role in the rise in youth vaping." The FDA acknowledged that it "has not received clinical information to suggest an immediate hazard associated" with the use of Juul's devices or pods, but said the agency issued its marketing denial orders (MDOs) against the company because "there is insufficient evidence to assess the potential toxicological risks" of using the products

Therefore, nicotine exposure during this critical period can lead to profound and rapid neuroadaptations in the brains reward pathways, specifically by influencing the dopamine and nicotinic acetylcholine receptors (nAChRs), increasing the susceptibility to addiction and decreasing the ability to control cravings 22