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You have gut issues that hamper B12 absorption While its true you need to consume vitamin B12 to benefit from it, the truth is that vitamin B12 deficiency often stems from difficulty absorbing the nutrients you eat due to conditions such as celiac disease, Crohns disease, thyroid disease, or gastric abnormalities

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How long B12 shots take to work depends on your B12 levels when you receive the injection, but you can expect to see improved energy, mental clarity, sleep, and other benefits anywhere from 12-48 hours after treatment