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In a meta-analysis examining the efficacy of metformin treatment for GDM, it was found that the incidence of severe neonatal hypoglycemia was significantly reduced in the metformin-treated GDM group, potentially due to improved maternal glycemic management (Nilsen et al., 2024

Select microbial metabolites in the small intestinal lumen regulate vagal activity via receptor-mediated signaling

Wise RMA, Wagener UM, Fietzek T, Klopstock EV, Mosharov FA, Zucca D, Sulzer L, Zecca LF, Burbulla

The adverse selection concern is real (people who want GLP-1s will shop for plans that cover them) and that is exactly why CMS set the 80% threshold so high

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It is worth noting that the changes in SIRTs activity and expression are closely related to the pathophysiological processes of kidney disease, including AKI and CKD (Perico et al., 2024)