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Ramya et al., 2022b

Cohort entry was defined as the date of the first-ever prescription for statins (statin users)

A proportion of CKD progresses to end-stage renal disease (ESRD), the prevalence and incidence of which significantly varies regionally

193,194 Tryptophan produced from lung fungi is converted to kynurenine by host indoleamine 2,3-dioxygenase, which causes an increase in Treg cells and a downregulation of Th17-mediated mucosal inflammation

Dorsey ER, Elbaz A, Nichols E, Abbasi N, Abd-Allah F, Abdelalim A, Adsuar JC, Ansha MG, Brayne C, Choi J-YJ (2018) Global, regional, and national burden of parkinsons disease, 19902016: a systematic analysis for the Global Burden of Disease Study 2016

Initially, NOX2 activation generates significant quantities of H 2 O 2 /O, which subsequently activate key signaling pathways such as MAPK and JNK, leading to nuclear membrane breakdown and chromatin decondensation, culminating in NET formation