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However, a recent meta-analysis including 812 ALS patients, 2632 controls from 9 studies identified no significant difference in plasma folic acid, Hcy and vitamin B12 levels between ALS patients and controls but showed elevated Hcy in CSF among ALS patients [185]

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Consequently, along with the filament classes, we observed 2D averages of this construct that represented these degradation products (Supplementary Fig

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