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In addition, TANK-binding kinase 1 (TBK1), a serine/threonine protein kinase with known functions in the innate immune pathway, 82,83 is co-recruited to depolarized mitochondria with OPTN and becomes activated

It is thought that NADPH prevents the formation of the inactive form of catalase (Compound II) and that it increases the rate of removal of this inactive form [45, 53, 55, 56]