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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Pappas AC, Zoidis E, Chadio SE

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Mitochondrial dysfunction, glutathione depletion, and inhibition of antioxidant enzymes such as superoxide dismutase (SOD) and catalase lead to ROS accumulation and oxidative DNA damage

Based on available evidence, the American Thoracic Society recommends augmentation therapy for individuals with both a documented severe deficiency of alpha 1-antitrypsin and fixed airflow obstruction

Immunostained slides were independently reviewed by senior pathologists (5 years experience) at the Department of Pathology, Fujian Medical University Union Hospital, who were blinded to all clinical information

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