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gemtuzumab ozogamicin (Mylotarg)

3E, Supplementary Fig

Human MPO is reported to have 467 amino acids in the large chain and 105 amino acids in its short chain

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doi: 10.1111/j.0105-2896.2005.00274.x [DOI] [PMC free article] [PubMed] [Google Scholar] 59

Specifically, we first prepared the intermediates, including Fmoc-CS, Fmoc-HDA and Fmoc-BSO, by modifying the disulfide bond linker, the control non-GSH responsive carboncarbon bond linker and BSO with 9-fluorenylmethyloxycarbonyl (Fmoc) group and succinic anhydride through liquid-phase reactions (Additional file 1: Figs