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Smoking and polysubstance use (p = 0.002 and p =0.059, respectively) were significantly higher in the not listed group while diabetes (p = 0.033), hypertension (p = 0.023), portal hypertension (p = 0.008), and spontaneous bacterial peritonitis (p =0.009) were more reported in the listed group

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NAD exists in two forms: the oxidised form (NAD+) and the reduced form (NADH)

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Cross response: hypoxia-NRF2 and oxidative stress-HIFs In real-world situations, the coexistence and interplay of hypoxia and oxidative stress result in a more complex response of HIFs and NRF2

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