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Individuals with Amyotrophic Lateral Sclerosis (ALS) also known as Lou Gehrig's disease or other conditions that impair the metabolism of BCAAs should avoid these supplements.7 In short, if you have any chronic medical condition or take an ongoing medication, talk with your doctor before beginning a BCAA or any over-the-counter dietary supplement

Generally, yes

Geier DA, Kern JK, Davis G, King PG, Adams JB, Young JL et al

Increased serum levels of the important biomarker PSA suggest that AR activity is elevated in prostate cancer patients

et al.: Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

Environmental Pollutants Red meat also contains contaminating inorganic toxins, such as arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), pesticides among many others (Domingo and Nadal, 2016)