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Several studies chose to validate their defined signatures in a secondary dataset and noted improved prediction of outcomes when metabolic biomarkers were used with protein biomarkers (S100b, UCH-L1, GFAP, etc.) [30, 31]

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Nonetheless, the categories represented in Table 5 do potentially correspond to conserved IIS-regulated processes

To uncover the mechanism of fructose protection against APAP-induced hepatotoxicity, we investigated the roles of fructose-induced hepatokine FGF21 and its transcription activator: carbohydrate-responsive element-binding protein (ChREBP)

This is part of the reason that mutations in the third position of a codon are often less disruptive than mutations in the first or second position

Two safety topics deserve emphasis: TMAO and cardiovascular signals