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Mechanistically, Arctigenin downregulated CPT1-mediated FAO, which further inhibited nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome assemblies in macrophages (Qiao et al., 2020)

Antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions: Talk to your, or your family members, healthcare provider about: - all risks and benefits of treatment with antidepressant medicines - all treatment choices for depression or other serious mental illness 1

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