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Results Glutathione depletion vulnerability Glutathione is not only the dominant coordinating ligand for cytosolic ferrous iron 22 but is also the substrate used by glutathione peroxidase-4 (GPX4) to clear the lipid peroxides that induce ferroptotic cell death 2527

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Nevertheless, available modalities and standards like, amyloid-PET imaging or cerebrospinal fluid studies, are costly and quite invasive to many patients