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PBD dimers show extreme potency but hepatotoxicity concerns in CRC, DXd-based ADCs demonstrate particular promise given their superior immunogenic cell death induction and favorable safety profiles, making them ideal for immunotherapy combinations (36)

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These data suggest GSTP1 palmitoylation is more stable and less dynamic than other palmitoylated proteins

Moreover, the availability of pharmacological agents capable of selectively regulating lipid metabolism with high precision remains limited due to the highly interconnected nature of lipid metabolic processes and their complex regulatory networks [113]

Lastly, syndromes of neurodegeneration with brain iron accumulation (NBIA), such as pantothenate kinase-associated neurodegeneration (PKAN), exemplify the devastating clinical effects of ferroptosis driven by excessive iron deposition

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